No association between transforming growth factor beta gene polymorphism and acute allograft rejection after cardiac transplantation.

@article{Bijlsma2002NoAB,
  title={No association between transforming growth factor beta gene polymorphism and acute allograft rejection after cardiac transplantation.},
  author={Femke J Bijlsma and Armando A van der Horst and M G J Tilanus and Erik H. Rozemuller and Nicolaas de Jonge and Frits H. J. Gmelig-Meyling and Roel A. de Weger},
  journal={Transplant immunology},
  year={2002},
  volume={10 1},
  pages={43-7}
}
Transforming growth factor-beta1 (TGF-beta1) is a multifunctional cytokine, which inhibits both development of Th1 and Th2 subsets and the Th1 proinflammatory response. TGF-beta1 production is influenced through several single nucleotide polymorphisms (SNP) in the structural gene and promoter region. Acute rejection of transplants depends on the Th1/Th2 balance within the graft, high levels of TGF-beta1 shift this balance towards Th2. We investigated whether genotypes of 4 SNP (-800 and -509 in… CONTINUE READING