No association between donor age and recipient outcomes: transfusion of plasma in patients undergoing coronary artery bypass grafting surgery

@article{Guinn2016NoAB,
  title={No association between donor age and recipient outcomes: transfusion of plasma in patients undergoing coronary artery bypass grafting surgery},
  author={Nicole R Guinn and Nathan H. Waldron and Mary L. Cooter and Corinne L. Goldberg and Miklos D. Kertai and Karthik Raghunathan and Nicholas Bandarenko and Maureane Hoffman and Elliott Bennett-Guerrero},
  journal={Transfusion},
  year={2016},
  volume={56}
}
Recent animal studies suggest that transfusion of plasma from young donors reverses age‐related neurologic and cardiac changes in older recipients. Associations between age of blood product donors and corresponding outcomes in recipients have not been studied in humans. Therefore, our primary objective was to examine this relationship between donor age and recipient outcomes among patients that received plasma during and after coronary artery bypass grafting (CABG) surgery. 
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References

SHOWING 1-10 OF 23 REFERENCES
A randomized controlled trial oftransfusion‐related acute lung injury: is plasma from multiparous blood donors dangerous?
TLDR
The effects of plasma from multiparous donors with those of plasmafrom donors with no history of transfusion or pregnancy (control plasma) are compared in a prospective, randomized, double‐blind, crossover study.
Preoperative CYP2D6 metabolism-dependent β-blocker use and mortality after coronary artery bypass grafting surgery.
Thrombomodulin Gene Variants Are Associated With Increased Mortality After Coronary Artery Bypass Surgery in Replicated Analyses
TLDR
In 2 independent cardiac surgery cohorts, linked common allelic variants in the THBD gene are independently associated with increased long-term mortality risk after CABG and significantly improve the classification ability of traditional postoperative mortality prediction models.
Transfusion-Related Acute Lung Injury: Current Concepts for the Clinician
  • D. Triulzi
  • Medicine, Biology
    Anesthesia and analgesia
  • 2009
The leading cause of transfusion-related morbidity and mortality in the United States is transfusion-related acute lung injury (TRALI). Diagnostic criteria for TRALI have recently been developed and
Genome-wide association study of acute kidney injury after coronary bypass graft surgery identifies susceptibility loci
TLDR
Through an unbiased GWAS approach, this study found two new loci associated with post-CABG AKI providing new insights into the pathogenesis of perioperative AKI.
Prolonged storage of packed red blood cells for blood transfusion.
TLDR
This Cochrane Review provides no evidence to support or reject the use of packed red blood cells for blood transfusion which have been stored for ≥ 21 days ('prolonged' or 'older') compared with those stored for <21 days ('fresh').
Detection, Evaluation, and Management of Anemia in the Elective Surgical Patient
TLDR
A panel of physicians was convened to develop a clinical care pathway for anemia management in the preoperative surgical setting, and found that the identification and evaluation of anemia in this setting will assist in expedited diagnosis and treatment of underlying comorbidities and will improve patient outcomes.
Logistic or additive EuroSCORE for high-risk patients?
  • P. Michel, F. Roques, S. Nashef
  • Medicine
    European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery
  • 2003
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