No association between atopy/asthma and the ILe50Val polymorphism of IL-4 receptor.

@article{Noguchi1999NoAB,
  title={No association between atopy/asthma and the ILe50Val polymorphism of IL-4 receptor.},
  author={Emiko Noguchi and Masanao Shibasaki and Tadao Arinami and Kazunori Takeda and Yukako Yokouchi and Kunihiko Kobayashi and Natsuki Imoto and Satoko Nakahara and Akira Matsui and Hideo Hamaguchi},
  journal={American journal of respiratory and critical care medicine},
  year={1999},
  volume={160 1},
  pages={342-5}
}
Susceptibility to atopic diseases is known to involve genetic factors. The interleukin-4 (IL-4) receptor- alpha gene (IL4R) reportedly is involved in the development of atopy. A recent study has shown the Ile50 allele of a polymorphism (Ile50Val) of IL4R to be associated with atopy. The objective of this study was to replicate this association and confirm the possible role of the Ile50Val polymorphism of IL4R in the etiology of atopic asthma in a Japanese population. We conducted a transmission… CONTINUE READING