No association between a functional polymorphism in the promoter region of the neuropeptide Y gene (-485C>T) and schizophrenia.

@article{Inoue2009NoAB,
  title={No association between a functional polymorphism in the promoter region of the neuropeptide Y gene (-485C>T) and schizophrenia.},
  author={Yoshiaki Inoue and Takahiro Shinkai and Kensuke Utsunomiya and Shinichi Sakata and Yuko Fukunaka and Wakana Yamaguchi and Kenji Yamada and Hsin-I Chen and R. L. Hwang and Osamu Ohmori and Jun - Ichi Sagara Shugo Nakamura},
  journal={Neuroscience letters},
  year={2009},
  volume={452 1},
  pages={72-4}
}
It has been suggested that hypoactivity of neuropeptide Y (NPY) may be involved in the pathophysiology of schizophrenia. A post-mortem study revealed a decreased level of NPY in the brain of patients with schizophrenia. An increased level of NPY after antipsychotic treatment was also reported in animal brain and cerebrospinal fluid of patients. Previously Itokawa et al. reported a positive association between the functional -485C>T polymorphism in the NPY gene and schizophrenia in a Japanese… CONTINUE READING