No alteration in gene expression of components of the ubiquitin-proteasome proteolytic pathway in dystrophin-deficient muscles.

@article{Combaret1996NoAI,
  title={No alteration in gene expression of components of the ubiquitin-proteasome proteolytic pathway in dystrophin-deficient muscles.},
  author={Lydie Combaret and Daniel Taillandier and Laure Voisin and Stuart E. Samuels and Odile Boespflug-Tanguy and Didier Attaix},
  journal={FEBS letters},
  year={1996},
  volume={393 2-3},
  pages={292-6}
}
Increased expression of critical components of the ubiquitin-dependent proteolytic pathway occurs in any muscle wasting condition so far studied in rodents where proteolysis rises. We have recently reported similar adaptations in head trauma patients [Mansoor et al. (1996) Proc. Natl. Acad. Sci. USA 93, 2714-2718]. We demonstrate here that the increased muscle protein breakdown seen in mdx mice only correlated with enhanced expression of m-calpain, a Ca(2+)-activated proteinase. By contrast, no… CONTINUE READING

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