No Transcription-Translation Feedback in Circadian Rhythm of KaiC Phosphorylation

@article{Tomita2005NoTF,
  title={No Transcription-Translation Feedback in Circadian Rhythm of KaiC Phosphorylation},
  author={Jun Tomita and Masato Nakajima and Takao Kondo and Hideo Iwasaki},
  journal={Science},
  year={2005},
  volume={307},
  pages={251 - 254}
}
An autoregulatory transcription-translation feedback loop is thought to be essential in generating circadian rhythms in any model organism. In the cyanobacterium Synechococcus elongatus, the essential clock protein KaiC is proposed to form this type of transcriptional negative feedback. Nevertheless, we demonstrate here temperature-compensated, robust circadian cycling of KaiC phosphorylation even without kaiBC messenger RNA accumulation under continuous dark conditions. This rhythm persisted… 
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