No Nogo66- and NgR-mediated inhibition of regenerating axons in the zebrafish optic nerve.

Abstract

In contrast to mammals, lesioned axons in the zebrafish (ZF) optic nerve regenerate and restore vision. This correlates with the absence of the NogoA-specific N-terminal domains from the ZF nogo/rtn-4 (reticulon-4) gene that inhibits regeneration in mammals. However, mammalian nogo/rtn-4 carries a second inhibitory C-terminal domain, Nogo-66, being 70… (More)
DOI: 10.1523/JNEUROSCI.3561-09.2009

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