No Hypersensitive Estrogen Receptor-α Mutation (K303R) in Japanese Breast Carcinomas

@article{Tokunaga2004NoHE,
  title={No Hypersensitive Estrogen Receptor-α Mutation (K303R) in Japanese Breast Carcinomas},
  author={Eriko Tokunaga and Yasue Kimura and Yoshihiko Maehara},
  journal={Breast Cancer Research and Treatment},
  year={2004},
  volume={84},
  pages={289-292}
}
Recently, a common somatic mutation, A-to-G transition at nucleotide 908, in the estrogen receptor-α (ERα) gene has been reported. This mutation causes an amino acid change in the ER hinge domain (lysine 303 to arginine, K303R) and confers an increased sensitivity to estrogen and an increased cellular proliferative potential. This mutation has been observed more frequently in breast cancers than in premalignant lesions. According to the previously published reports, the mutation was found in 62… CONTINUE READING

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