No Evidence of a Causal Relationship between Plasma Homocysteine and Type 2 Diabetes: A Mendelian Randomization Study

@inproceedings{Kumar2015NoEO,
  title={No Evidence of a Causal Relationship between Plasma Homocysteine and Type 2 Diabetes: A Mendelian Randomization Study},
  author={Jitender Kumar and Erik Ingelsson and Lars Lind and Tove Fall},
  booktitle={Front. Cardiovasc. Med.},
  year={2015}
}
BACKGROUND Several observational studies have shown an association between increased circulating homocysteine and risk of type 2 diabetes (T2D). We aimed to assess whether this relation is causal using genetic data from large populations of individuals of European descent. METHODS We investigated the association between homocysteine concentrations and blood glucose, plasma insulin, T2D in the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) cohort (n = 1,016). A score… CONTINUE READING