No Evidence for the Benefit of Gonadotropin-Releasing Hormone Agonist in Preserving Ovarian Function and Fertility in Lymphoma Survivors Treated With Chemotherapy: Final Long-Term Report of a Prospective Randomized Trial

@article{Demeestere2016NoEF,
  title={No Evidence for the Benefit of Gonadotropin-Releasing Hormone Agonist in Preserving Ovarian Function and Fertility in Lymphoma Survivors Treated With Chemotherapy: Final Long-Term Report of a Prospective Randomized Trial},
  author={Isabelle Demeestere and Pauline Brice and Fedro Alessandro Peccatori and Alain Kentos and Jehan Dupuis and Pierre Zach{\'e}e and Olivier Casasnovas and Eric Van Den Neste and Julie Dech{\`e}ne and Viviane de Maertelaer and Dominique Bron and Yvon Englert},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={2016},
  volume={34 22},
  pages={
          2568-74
        }
}
PURPOSE We have reported previously that after 1-year follow up, gonadotropin-releasing hormone agonist (GnRHa) did not prevent chemotherapy-induced premature ovarian failure (POF) in patients with lymphoma, but may provide protection of the ovarian reserve. Here, we report the final analysis of the cohort after 5 years of follow up. PATIENTS AND METHODS A total of 129 patients with lymphoma were randomly assigned to receive either triptorelin plus norethisterone (GnRHa group) or… CONTINUE READING

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