No Evidence for Enhancement of Spatial Ability with Elevated Prenatal Androgen Exposure in Congenital Adrenal Hyperplasia: A Meta-Analysis

@article{Collaer2020NoEF,
  title={No Evidence for Enhancement of Spatial Ability with Elevated Prenatal Androgen Exposure in Congenital Adrenal Hyperplasia: A Meta-Analysis},
  author={Marcia L. Collaer and Melissa Hines},
  journal={Archives of Sexual Behavior},
  year={2020},
  volume={49},
  pages={395-411}
}
Spatial abilities contribute to life and occupational competencies, and certain spatial skills differ, on average, between males and females, typically favoring males when differences occur. Factors contributing to spatial skills could include prenatal as well as experiential/cultural influences, with biological and social influences likely interacting and difficult to disentangle. This meta-analysis examined the potential influence of prenatal androgen exposure on spatial skill by examining… 

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References

SHOWING 1-10 OF 123 REFERENCES

Spatial Ability and Prenatal Androgens: Meta-Analyses of Congenital Adrenal Hyperplasia and Digit Ratio (2D:4D) Studies

TLDR
Meta-analyses of published literature and unpublished results to determine if either of these indicators of prenatal androgens predicts performance on spatial tasks that show a male advantage indicated that females with CAH perform better on these spatial tasks, and CAH males perform worse, than do controls.

Early androgen effects on spatial and mechanical abilities: evidence from congenital adrenal hyperplasia.

TLDR
Findings indicate that early androgens influence spatial and mechanical abilities, and that androgen effects on abilities may occur in part through effects on sex-typed activity interests.

Prenatal androgen exposure alters girls' responses to information indicating gender-appropriate behaviour

TLDR
It is reported that girls exposed to high concentrations of androgens prenatally, because they have the genetic condition congenital adrenal hyperplasia, show changes in processes related to self-socialization of gender-related behaviour, and this suggests that some of the behavioural effects of prenatal androgen exposure might be subject to alteration by postnatal socialization processes.

Spatial ability in androgen-deficient men.

TLDR
The impairment in spatial ability in men with the idiopathic form of hypogonadotropic hypogOnadism, the lack of such an impairment inMen with the acquired form, and the failure to exogenous androgens to correct the deficits in the idiospecific form suggest that androgens exert a permanent organizing influence on the brain before or at puberty in boys.

Sex-typed toy play behavior correlates with the degree of prenatal androgen exposure assessed by CYP21 genotype in girls with congenital adrenal hyperplasia.

TLDR
The results support the view that prenatal androgen exposure has a direct organizational effect on the human brain to determine certain aspects of sex-typed behavior.

Early androgen exposure and human gender development

TLDR
The postnatal surge in testosterone in male infants, sometimes called mini-puberty, may provide a more accessible opportunity for measuring early androgen exposure during typical development, with some promising results relating testosterone during the first few months of postnatal life to later gender-typical play behavior.

Cognitive Outcome in Adult Women Affected by Congenital Adrenal Hyperplasia due to 21-Hydroxylase Deficiency

TLDR
The findings provide additional support for the conclusion that, in adult women with CAH, previous prenatal androgen exposure does not enhance spatial abilities, impair verbal abilities nor alter hand preferences in a long-lasting way.
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