No Association of Abacavir Use With Myocardial Infarction: Findings of an FDA Meta-Analysis

@article{Ding2012NoAO,
  title={No Association of Abacavir Use With Myocardial Infarction: Findings of an FDA Meta-Analysis},
  author={X. Ding and Eugenio Andraca-Carrera and C. Cooper and P. Miele and C. Kornegay and M. Soukup and Kendall A Marcus},
  journal={JAIDS Journal of Acquired Immune Deficiency Syndromes},
  year={2012},
  volume={61},
  pages={441–447}
}
  • X. Ding, Eugenio Andraca-Carrera, +4 authors Kendall A Marcus
  • Published 2012
  • Medicine
  • JAIDS Journal of Acquired Immune Deficiency Syndromes
  • Background:Several studies have reported an association between abacavir (ABC) exposure and increased risk of myocardial infarction (MI) among HIV-infected individuals. Randomized controlled trials (RCTs) and a pooled analysis by GlaxoSmithKline, however, do not support this association. To better estimate the effect of ABC use on risk of MI, the US Food and Drug Administration (FDA) conducted a trial-level meta-analysis of RCTs in which ABC use was randomized as part of a combined… CONTINUE READING
    154 Citations

    Paper Mentions

    Blog Post
    Abacavir Use and Risk for Myocardial Infarction and Cardiovascular Events: Pooled Analysis of Data From Clinical Trials
    • 11
    • PDF
    Abacavir and cardiovascular disease: A critical look at the data.
    • 19
    • Highly Influenced
    • PDF
    Risk of Cardiovascular Disease from Antiretroviral Therapy for HIV: A Systematic Review
    • 172
    • PDF
    Abacavir use and risk of recurrent myocardial infarction: the D: A: D study
    • 8
    • PDF
    Recent Abacavir Use Increases Risk of Type 1 and Type 2 Myocardial Infarctions Among Adults With HIV
    • 26
    Abacavir use and risk of recurrent myocardial infarction
    • 9
    • PDF
    Cardiovascular toxicity of abacavir: a clinical controversy in need of a pharmacological explanation
    • 20
    Virological efficacy of abacavir: systematic review and meta-analysis.
    • 19
    • PDF

    References

    SHOWING 1-10 OF 40 REFERENCES
    Risk of Myocardial Infarction and Abacavir Therapy: No Increased Risk Across 52 GlaxoSmithKline-Sponsored Clinical Trials in Adult Subjects
    • 169
    • PDF
    No risk of myocardial infarction associated with initial antiretroviral treatment containing abacavir: short and long-term results from ACTG A5001/ALLRT.
    • H. Ribaudo, C. Benson, +7 authors J. Schouten
    • Medicine
    • Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
    • 2011
    • 133
    • PDF
    Combination antiretroviral therapy and the risk of myocardial infarction.
    • 1,253
    • PDF
    Class of antiretroviral drugs and the risk of myocardial infarction.
    • 1,031
    • PDF
    Less Lipoatrophy and Better Lipid Profile With Abacavir as Compared to Stavudine: 96-Week Results of a Randomized Study
    • 128