No Association of Abacavir Use With Myocardial Infarction: Findings of an FDA Meta-Analysis

@article{Ding2012NoAO,
  title={No Association of Abacavir Use With Myocardial Infarction: Findings of an FDA Meta-Analysis},
  author={Xiao Ding and Eugenio Andraca-Carrera and Charles K. Cooper and Peter S Miele and Cynthia J. Kornegay and Mat Soukup and Kendall A Marcus},
  journal={JAIDS Journal of Acquired Immune Deficiency Syndromes},
  year={2012},
  volume={61},
  pages={441–447}
}
Background:Several studies have reported an association between abacavir (ABC) exposure and increased risk of myocardial infarction (MI) among HIV-infected individuals. Randomized controlled trials (RCTs) and a pooled analysis by GlaxoSmithKline, however, do not support this association. To better estimate the effect of ABC use on risk of MI, the US Food and Drug Administration (FDA) conducted a trial-level meta-analysis of RCTs in which ABC use was randomized as part of a combined… 
Abacavir Use and Risk for Myocardial Infarction and Cardiovascular Events: Pooled Analysis of Data From Clinical Trials
TLDR
A pooled analysis of 66 phase II–IV RCTs found comparable IRs for MI and CVEs among ABC-exposed and -unexposed participants, suggesting no increased risk for MI or CVEs following ABC exposure in a clinical trial population.
Is there continued evidence for an association between abacavir usage and myocardial infarction risk in individuals with HIV? A cohort collaboration
TLDR
Despite a reduction in the channelling of ABC for patients at higher CVD risk since 2008, an association between ABC use and MI risk is observed, and confounding cannot be fully ruled out.
Abacavir and cardiovascular disease: A critical look at the data.
Effects of Combination Antiretroviral Therapies on the Risk of Myocardial Infarction Among HIV Patients
TLDR
An increased rate of MI among patients initiating abacavir compared with tenofovir, although the association was decreased after confounding adjustment, and a much larger observational study of patients initiating cART would be needed to better define this apparent association.
Risk of Cardiovascular Disease from Antiretroviral Therapy for HIV: A Systematic Review
TLDR
The findings that implicate specific ARTs in the observational setting provide sufficient evidence to warrant further investigation of this relationship in studies designed for that purpose.
Abacavir use and risk of recurrent myocardial infarction: the D: A: D study
TLDR
There was no evidence for an association between use of ABC post-MI and an elevated risk of a recurrent MI among HIV-positive people with a prior MI.
Recent Abacavir Use Increases Risk of Type 1 and Type 2 Myocardial Infarctions Among Adults With HIV
TLDR
Recent ABC use was associated with MI after adjustment for known risk factors and for FRS, however, screening for T1MI risks may not identify all or even most persons at risk of ABC use-associated MIs.
Abacavir use and risk of recurrent myocardial infarction
TLDR
There was no evidence for an association between use of ABC post-MI and an elevated risk of a recurrent MI among HIV-positive people with a prior MI.
Cardiovascular toxicity of abacavir: a clinical controversy in need of a pharmacological explanation
TLDR
The present review aims to shed light on this complex subject by summarizing and critically evaluating all the available clinical data regarding a relationship between ABC and cardiovascular disease, and to put forward potential pharmacological explanations compatible with both the clinical scenario and experimental findings.
Virological efficacy of abacavir: systematic review and meta-analysis.
TLDR
The authors' cumulative, cross-sectional data suggest a similar virological efficacy of abacavir/lamivudine and tenofovir/emtricitabine regardless of the baseline VL, as well as differences in the occurrence of adverse events requiring discontinuation of treatment.
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