No Association Between CEL-HYB Hybrid Allele and Chronic Pancreatitis in Asian Populations.

@article{Zou2016NoAB,
  title={No Association Between CEL-HYB Hybrid Allele and Chronic Pancreatitis in Asian Populations.},
  author={Wen-Bin Zou and Arnaud Boulling and Atsushi Masamune and Prachand Issarapu and Emmanuelle Masson and Hao Wu and Xiao-Tian Sun and Liang-hao Hu and Dai-zhan Zhou and Lin He and Yann Fichou and Eriko Nakano and Shin Hamada and Yoichi Kakuta and Kiyoshi Kume and Hiroyuki Isayama and Sumit Paliwal and Kulathu Radha Mani and S Uday Bhaskar and David N. Cooper and Claude F{\'e}rec and Tooru Shimosegawa and Giriraj Ratan Chandak and Jian-Min Chen and Zhao Shen Li and Zhuan Liao},
  journal={Gastroenterology},
  year={2016},
  volume={150 7},
  pages={1558-1560.e5}
}
A hybrid allele between the carboxyl ester lipase gene (CEL) and its pseudogene, CELP (called CEL-HYB), generated by nonallelic homologous recombination between CEL intron 10 and CELP intron 10', was found to increase susceptibility to chronic pancreatitis in a case-control study of patients of European ancestry. We attempted to replicate this finding in 3 independent cohorts from China, Japan, and India, but failed to detect the CEL-HYB allele in any of these populations. The CEL-HYB allele… CONTINUE READING
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