Nm23-h1 indirectly promotes the survival of acute myeloid leukemia blast cells by binding to more mature components of the leukemic clone.

@article{Lilly2011Nm23h1IP,
  title={Nm23-h1 indirectly promotes the survival of acute myeloid leukemia blast cells by binding to more mature components of the leukemic clone.},
  author={Andrew Joshua Lilly and Farhat L Khanim and Rachel Elizabeth Hayden and Quang Trong Luong and Mark Trehane Drayson and Christopher M. Bunce},
  journal={Cancer research},
  year={2011},
  volume={71 3},
  pages={
          1177-86
        }
}
Nm23-H1 plays complex roles in the development of diverse cancers including breast carcinoma, high-grade lymphomas, and acute myeloid leukemia (AML). In the case of AML and lymphomas, serum Nm23-H1 protein is elevated with the highest levels correlating with poorest prognosis. A recent study identified that this association is most likely causal in AML and that Nm23-H1 acts as an AML cell survival factor. In this study, we report heterogeneity in the ability of AML samples to bind and respond… CONTINUE READING

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