NleG Type 3 Effectors from Enterohaemorrhagic Escherichia coli Are U-Box E3 Ubiquitin Ligases

  title={NleG Type 3 Effectors from Enterohaemorrhagic Escherichia coli Are U-Box E3 Ubiquitin Ligases},
  author={B. Wu and T. Skarina and A. Yee and Marie-Claude Jobin and Rosa DiLeo and A. Semesi and Christophe Far{\`e}s and A. Lemak and B. Coombes and C. Arrowsmith and A. Singer and A. Savchenko},
  journal={PLoS Pathogens},
  • B. Wu, T. Skarina, +9 authors A. Savchenko
  • Published 2010
  • Biology, Medicine
  • PLoS Pathogens
  • NleG homologues constitute the largest family of type 3 effectors delivered by pathogenic E. coli, with fourteen members in the enterohaemorrhagic (EHEC) O157:H7 strain alone. Identified recently as part of the non-LEE-encoded (Nle) effector set, this family remained uncharacterised and shared no sequence homology to other proteins including those of known function. The C-terminal domain of NleG2-3 (residues 90 to 191) is the most conserved region in NleG proteins and was solved by NMR… CONTINUE READING
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