Nkx3-1 and LEF-1 function as transcriptional inhibitors of estrogen receptor activity.

@article{Holmes2008Nkx31AL,
  title={Nkx3-1 and LEF-1 function as transcriptional inhibitors of estrogen receptor activity.},
  author={Kelly A. Holmes and Jun S Song and Xiaole Shirley Liu and Myles Brown and Jason S. Carroll},
  journal={Cancer research},
  year={2008},
  volume={68 18},
  pages={
          7380-5
        }
}
Estrogen receptor (ER)-associated cofactors and cooperating transcription factors are one of the primary components determining transcriptional activity of estrogen target genes and may constitute potential therapeutic targets. Recent mapping of ER-binding sites on a genome-wide scale has provided insight into novel cooperating factors based on the enrichment of transcription factor motifs within the ER-binding sites. We have used the ER-binding sites in combination with sequence conservation… CONTINUE READING

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