Nkx2.1 transcription factor in lung cells and a transforming growth factor-beta1 heterozygous mouse model of lung carcinogenesis.

@article{Kang2004Nkx21TF,
  title={Nkx2.1 transcription factor in lung cells and a transforming growth factor-beta1 heterozygous mouse model of lung carcinogenesis.},
  author={Yang Kang and Haroun R Hebron and Laurent L Ozbun and Jennifer Mariano and Parviz Minoo and Sonia B. Jakowlew},
  journal={Molecular carcinogenesis},
  year={2004},
  volume={40 4},
  pages={212-31}
}
The Nkx2.1 homeobox gene and transforming growth factor-beta1 (TGF-beta1) are essential for organogenesis and differentiation of the mouse lung. NKX2.1 is a marker of human lung carcinomas, but it is not known whether this gene participates in early tumorigenesis. Addition of TGF-beta1 to TGF-beta1-responsive nontumorigenic mouse lung cells cotransfected with a NKX2.1Luc luciferase reporter and either a Sp1 or Sp3 plasmid showed a significant increase or decrease, respectively, in NKX2.1Luc… CONTINUE READING
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