Nkx2-8 downregulation promotes angiogenesis and activates NF-κB in esophageal cancer.

@article{Lin2013Nkx28DP,
  title={Nkx2-8 downregulation promotes angiogenesis and activates NF-κB in esophageal cancer.},
  author={Chuyong Lin and Libing Song and Hui Gong and Aibin Liu and Xi Xi Lin and Jueheng Wu and Mengfeng Li and Jun Li},
  journal={Cancer research},
  year={2013},
  volume={73 12},
  pages={
          3638-48
        }
}
Angiogenesis is a major clinical feature of esophageal squamous cell carcinoma (ESCC), an aggressive disease of increasing incidence in developed countries. In ESCCs, the proangiogenic factor VEGF-C is an independent prognostic factor for ESCC, where understanding the mechanisms of VEGF-C upregulation may cue possible therapeutic insights. Here, we report that expression of the transcription factor Nkx2-8 is downregulated in ESCCs where it inversely correlates with progression and VEGF-C… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 23 CITATIONS

References

Publications referenced by this paper.
SHOWING 1-10 OF 42 REFERENCES

Comparison of the effect of p65 siRNA and curcumin in promoting apoptosis in esophageal squamous cell carcinoma cells and in nude mice

F Tian, C Zhang, TianW, Y Jiang, X. Zhang
  • Oncol Rep
  • 2012

Both gene amplification and allelic loss occur at 14q13.3 in lung cancer.

  • Clinical cancer research : an official journal of the American Association for Cancer Research
  • 2011
VIEW 2 EXCERPTS

Clinical significance of GPR56, transglutaminase 2, and NFkB in esophageal squamous cell carcinoma

T Kausar, SharmaR, +3 authors TK Chattopadhyay
  • Cancer Invest
  • 2011

A-kinase-interacting protein 1 (AKIP1) acts asamolecular determinant ofPKA inNF-kappaB signaling

GaoN, Y Hibi, CuenoM, K Asamitsu, T. Okamoto
  • J Biol Chem 2010;285:28097–104
  • 2010