Nkx2-5 activity is essential for cardiomyogenesis.


The homeobox transcription factor tinman is essential for heart vessel formation in Drosophila. In contrast, mice lacking the murine homologue Nkx2-5 are defective in cardiac looping but not in cardiac myocyte development. The lack of an essential role for Nkx2-5 in cardiomyogenesis in mammalian systems is most likely the result of genetic redundancy with… (More)


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@article{Jamali2001Nkx25AI, title={Nkx2-5 activity is essential for cardiomyogenesis.}, author={Mohsen Jamali and Parker J Rogerson and S Wilton and Ilona S. Skerjanc}, journal={The Journal of biological chemistry}, year={2001}, volume={276 45}, pages={42252-8} }