Nizp1, a novel multitype zinc finger protein that interacts with the NSD1 histone lysine methyltransferase through a unique C2HR motif.

@article{Nielsen2004Nizp1AN,
  title={Nizp1, a novel multitype zinc finger protein that interacts with the NSD1 histone lysine methyltransferase through a unique C2HR motif.},
  author={Anders Lade Nielsen and Poul J\orgensen and Thierry Lerouge and Margarita Cervi{\~n}o and Pierre Chambon and R{\'e}gine Losson},
  journal={Molecular and cellular biology},
  year={2004},
  volume={24 12},
  pages={5184-96}
}
Haploinsufficiency of the NSD1 gene is a hallmark of Sotos syndrome, and rearrangements of this gene by translocation can cause acute myeloid leukemia. The NSD1 gene product is a SET-domain histone lysine methyltransferase that has previously been shown to interact with nuclear receptors. We describe here a novel NSD1-interacting protein, Nizp1, that contains a SCAN box, a KRAB-A domain, and four consensus C2H2-type zinc fingers preceded by a unique finger derivative, referred to herein as the… CONTINUE READING

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