Nitroxyl inhibits breast tumor growth and angiogenesis.

  title={Nitroxyl inhibits breast tumor growth and angiogenesis.},
  author={Andrew J Norris and Maryam Radimeh Sartippour and Ming Lu and Taylor Park and Jian Yu Rao and Matthew I. Jackson and Jon M Fukuto and Mai N Brooks},
  journal={International journal of cancer},
  volume={122 8},
Nitroxyl (HNO) can inhibit the glycolytic enzyme glyceraldehyde 3-phosphate dehydrogenase (GAPDH). Because of the importance of glycolysis in many malignant cells, we thus propose that HNO can adversely affect tumor growth. This hypothesis was tested using in vitro and in vivo models of breast cancer. We report here for the first time that HNO suppresses the proliferation of both estrogen receptor (ER)-positive and ER-negative human breast cancer cell lines, in a dose dependent manner. Mice… CONTINUE READING
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