Nitroxyl improves cellular heart function by directly enhancing cardiac sarcoplasmic reticulum Ca2+ cycling.

@article{Tocchetti2007NitroxylIC,
  title={Nitroxyl improves cellular heart function by directly enhancing cardiac sarcoplasmic reticulum Ca2+ cycling.},
  author={Carlo Gabriele Tocchetti and Wang Wang and Jeffrey P. Froehlich and Sabine Huke and Miguel Antonio Aon and Gerald M. Wilson and Giulietta Di Benedetto and Brian O'Rourke and Wei Gao and David A Wink and John P. Toscano and Manuela Zaccolo and Donald M. Bers and H{\'e}ctor H. Valdivia and Heping Cheng and David A. Kass and Nazareno Paolocci},
  journal={Circulation research},
  year={2007},
  volume={100 1},
  pages={96-104}
}
Heart failure remains a leading cause of morbidity and mortality worldwide. Although depressed pump function is common, development of effective therapies to stimulate contraction has proven difficult. This is thought to be attributable to their frequent reliance on cAMP stimulation to increase activator Ca(2+). A potential alternative is nitroxyl (HNO), the 1-electron reduction product of nitric oxide (NO) that improves contraction and relaxation in normal and failing hearts in vivo. The… CONTINUE READING