Nitroxidative Signaling Mechanisms in Pathological Pain.

Abstract

Tissue injury can initiate bidirectional signaling between neurons, glia, and immune cells that creates and amplifies pain. While the ability for neurotransmitters, neuropeptides, and cytokines to initiate and maintain pain has been extensively studied, recent work has identified a key role for reactive oxygen and nitrogen species (ROS/RNS; nitroxidative… (More)
DOI: 10.1016/j.tins.2016.10.003

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