Nitrous oxide enhances Na+/Ca++ exchange in the neuroblastoma cell line SK-N-SH.

@article{Resendes1997NitrousOE,
  title={Nitrous oxide enhances Na+/Ca++ exchange in the neuroblastoma cell line SK-N-SH.},
  author={Mariela Resendes and G C Kalogeros and S. Jeffrey Dixon and Richard B. Philp},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1997},
  volume={280 2},
  pages={795-801}
}
Changes in the concentration of cytosolic free calcium ([Ca++]i) play fundamental roles in the initiation and regulation of many neuronal processes. Altered regulation of [Ca++]i has been implicated in the action of some anesthetics. We investigated the effects of nitrous oxide (N2O) on Ca++ mobilization and membrane potential in the human neuroblastoma cell line SK-N-SH. [Ca++]i was monitored by fluorescence spectrophotometry of cells loaded with fura-2 or fluo-3. N2O reversibly suppressed… CONTINUE READING