Nitrous oxide and risk of surgical wound infection: a randomised trial.

@article{Fleischmann2005NitrousOA,
  title={Nitrous oxide and risk of surgical wound infection: a randomised trial.},
  author={Edith Fleischmann and Rainer Lenhardt and Andrea Kurz and Friedrich Herbst and B{\'e}la F{\"u}lesdi and Robert Greif and Daniel I Sessler and Ozan Akça},
  journal={Lancet},
  year={2005},
  volume={366 9491},
  pages={1101-7}
}
BACKGROUND Nitrous oxide inactivates vitamin B12 and methionine synthase, thereby impairing DNA formation and, consequently, new cell formation. The gas also inhibits methionine production, which can reduce scar formation and depresses chemotactic migration by monocytes. Therefore, we assessed whether nitrous oxide increases the incidence of surgical wound infection. METHODS We recruited 418 patients aged 18-80 years, scheduled for colon resection that was expected to last more than 2 h, at… CONTINUE READING
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