Nitrotyrosine proteome survey in asthma identifies oxidative mechanism of catalase inactivation.

@article{Ghosh2006NitrotyrosinePS,
  title={Nitrotyrosine proteome survey in asthma identifies oxidative mechanism of catalase inactivation.},
  author={Sudakshina Ghosh and Allison J. Janocha and Mark A. Aronica and Shadi Swaidani and Suzy A. A. Comhair and Weiling Xu and Lemin Zheng and Suma Kaveti and Michael Kinter and Stanley L. Hazen and Serpil C. Erzurum},
  journal={Journal of immunology},
  year={2006},
  volume={176 9},
  pages={5587-97}
}
Reactive oxygen species and reactive nitrogen species produced by epithelial and inflammatory cells are key mediators of the chronic airway inflammation of asthma. Detection of 3-nitrotyrosine in the asthmatic lung confirms the presence of increased reactive oxygen and nitrogen species, but the lack of identification of modified proteins has hindered an understanding of the potential mechanistic contributions of nitration/oxidation to airway inflammation. In this study, we applied a proteomic… CONTINUE READING
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