Nitrotyrosine in plasma of celiac disease patients as detected by a new sandwich ELISA.

@article{Steege1998NitrotyrosineIP,
  title={Nitrotyrosine in plasma of celiac disease patients as detected by a new sandwich ELISA.},
  author={Jessica ter Steege and Linda Koster-Kamphuis and E A van Straaten and P. P. Forget and Wim A. Buurman},
  journal={Free radical biology & medicine},
  year={1998},
  volume={25 8},
  pages={953-63}
}
Inflammation is characterized by increased nitric oxide production. Nitrotyrosine has recently been suggested to be useful as a marker for NO-mediated tissue damage. In context of the development of an ELISA for detection of nitrotyrosine in plasma, monoclonal anti-nitrotyrosine antibodies were developed by injecting mice with nitrated keyhole limpet hemocyanin. The specificity of the antibodies was determined by binding to nitrated BSA, lack of binding to unmodified BSA, tyrosine, 3… CONTINUE READING

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