Nitrotriazole-based acetamides and propanamides with broad spectrum antitrypanosomal activity

  title={Nitrotriazole-based acetamides and propanamides with broad spectrum antitrypanosomal activity},
  author={Maria V. Papadopoulou and William D. Bloomer and Howard S. Rosenzweig and Shane R. Wilkinson and Joanna Szular and M Kaiser},
  booktitle={European journal of medicinal chemistry},
3-Nitro-1H-1,2,4-triazole-based acetamides bearing a biphenyl- or a phenoxyphenyl moiety have shown remarkable antichagasic activity both in vitro and in an acute murine model, as well as substantial in vitro antileishmanial activity but lacked activity against human African trypanosomiasis. We have shown now that by inserting a methylene group in the linkage to obtain the corresponding propanamides, both antichagasic and in particular anti-human African trypanosomiasis potency was increased… CONTINUE READING
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