Nitrosyl-heme complexes are formed in the ischemic heart: evidence of nitrite-derived nitric oxide formation, storage, and signaling in post-ischemic tissues.

@article{Tiravanti2004NitrosylhemeCA,
  title={Nitrosyl-heme complexes are formed in the ischemic heart: evidence of nitrite-derived nitric oxide formation, storage, and signaling in post-ischemic tissues.},
  author={Edy Altea Tiravanti and Alexandre Samouilov and Jay L. Zweier},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 12},
  pages={11065-73}
}
In addition to the generation from specific nitric-oxide (NO) synthases, NO formation from nitrite occurs in ischemic tissues, such as the heart. Although NO binding to heme-centers is the basis for NO-mediated signaling as occurs through guanylate cyclase, it is not known if this process is triggered with physiologically relevant periods of sublethal ischemia and if nitrite serves as a critical substrate. Therefore electron paramagnetic resonance studies were performed to measure nitrosylheme… CONTINUE READING
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