Nitrosopersulfide (SSNO−) accounts for sustained NO bioactivity of S-nitrosothiols following reaction with sulfide☆

@article{CorteseKrott2014NitrosopersulfideA,
  title={Nitrosopersulfide (SSNO−) accounts for sustained NO bioactivity of S-nitrosothiols following reaction with sulfide☆},
  author={M. Cortese-Krott and Bernadette O. Fernandez and J. L. Santos and E. Mergia and M. Grman and P. Nagy and M. Kelm and A. Butler and M. Feelisch},
  journal={Redox Biology},
  year={2014},
  volume={2},
  pages={234 - 244}
}
  • M. Cortese-Krott, Bernadette O. Fernandez, +6 authors M. Feelisch
  • Published 2014
  • Chemistry, Medicine
  • Redox Biology
  • Sulfide salts are known to promote the release of nitric oxide (NO) from S-nitrosothiols and potentiate their vasorelaxant activity, but much of the cross-talk between hydrogen sulfide and NO is believed to occur via functional interactions of cell regulatory elements such as phosphodiesterases. Using RFL-6 cells as an NO reporter system we sought to investigate whether sulfide can also modulate nitrosothiol-mediated soluble guanylyl cyclase (sGC) activation following direct chemical… CONTINUE READING
    104 Citations
    Nitrosopersulfide (SSNO-) targets the Keap-1/Nrf2 redox system.
    • 14
    On the chemical biology of the nitrite/sulfide interaction.
    • 67
    Hydrogen Sulfide and Polysulfides as Biological Mediators
    • 108
    • PDF
    The reaction products of sulfide and S-nitrosoglutathione are potent vasorelaxants.
    • 47
    • PDF
    Inorganic Reactive Sulfur-Nitrogen Species: Intricate Release Mechanisms or Cacophony in Yellow, Blue and Red?
    • 8
    • PDF
    Hydrogen sulfide in pharmacology and medicine--An update.
    • 96

    References

    SHOWING 1-10 OF 93 REFERENCES
    Polysulfides link H2S to protein thiol oxidation.
    • 280
    Hydrogen Sulfide Is an Endogenous Inhibitor of Phosphodiesterase Activity
    • 237
    • Highly Influential
    • PDF
    Potential biological chemistry of hydrogen sulfide (H2S) with the nitrogen oxides.
    • 18
    The chemical biology of S-nitrosothiols.
    • 170
    Evidence for the formation of a novel nitrosothiol from the gaseous mediators nitric oxide and hydrogen sulphide.
    • 309
    • Highly Influential
    Bioassay discrimination between nitric oxide (NO.) and nitroxyl (NO-) using L-cysteine.
    • R. Pino, M. Feelisch
    • Chemistry, Medicine
    • Biochemical and biophysical research communications
    • 1994
    • 108
    Reactivity of sulfur nucleophiles towards S-nitrosothiols
    • 38
    • Highly Influential
    Production and physiological effects of hydrogen sulfide.
    • H. Kimura
    • Medicine, Biology
    • Antioxidants & redox signaling
    • 2014
    • 160