• DOI:10.1016/j.redox.2013.12.031
Corpus ID: 15866527

Nitrosopersulfide (SSNO−) accounts for sustained NO bioactivity of S-nitrosothiols following reaction with sulfide☆

@article{CorteseKrott2014NitrosopersulfideA,
  title={Nitrosopersulfide (SSNO−) accounts for sustained NO bioactivity of S-nitrosothiols following reaction with sulfide☆},
  author={M. Cortese-Krott and Bernadette O. Fernandez and J. L. Santos and E. Mergia and M. Grman and P. Nagy and M. Kelm and A. Butler and M. Feelisch},
  journal={Redox Biology},
  year={2014},
  volume={2},
  pages={234 - 244}
}

M. Cortese-Krott, Bernadette O. Fernandez, +6 authors M. Feelisch

Published 2014

Chemistry, Medicine

Redox Biology

Sulfide salts are known to promote the release of nitric oxide (NO) from S-nitrosothiols and potentiate their vasorelaxant activity, but much of the cross-talk between hydrogen sulfide and NO is believed to occur via functional interactions of cell regulatory elements such as phosphodiesterases. Using RFL-6 cells as an NO reporter system we sought to investigate whether sulfide can also modulate nitrosothiol-mediated soluble guanylyl cyclase (sGC) activation following direct chemical… CONTINUE READING

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