Nitrosopersulfide (SSNO−) accounts for sustained NO bioactivity of S-nitrosothiols following reaction with sulfide☆

  title={Nitrosopersulfide (SSNO−) accounts for sustained NO bioactivity of S-nitrosothiols following reaction with sulfide☆},
  author={M. Cortese-Krott and Bernadette O. Fernandez and J. L. Santos and E. Mergia and M. Grman and P. Nagy and M. Kelm and A. Butler and M. Feelisch},
  journal={Redox Biology},
  pages={234 - 244}
  • M. Cortese-Krott, Bernadette O. Fernandez, +6 authors M. Feelisch
  • Published 2014
  • Chemistry, Medicine
  • Redox Biology
  • Sulfide salts are known to promote the release of nitric oxide (NO) from S-nitrosothiols and potentiate their vasorelaxant activity, but much of the cross-talk between hydrogen sulfide and NO is believed to occur via functional interactions of cell regulatory elements such as phosphodiesterases. Using RFL-6 cells as an NO reporter system we sought to investigate whether sulfide can also modulate nitrosothiol-mediated soluble guanylyl cyclase (sGC) activation following direct chemical… CONTINUE READING
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