Nitrosative stress induces proliferation and viability changes in high glucose-exposed rat Schwannoma cells.

@article{Gadau2012NitrosativeSI,
  title={Nitrosative stress induces proliferation and viability changes in high glucose-exposed rat Schwannoma cells.},
  author={Sergio Domenico Gadau},
  journal={Neuro endocrinology letters},
  year={2012},
  volume={33 3},
  pages={279-84}
}
OBJECTIVES Schwann cells may be involved in the pathogenesis of several neuropathies, such as those linked to an excess of d-glucose. Indeed, hyperglicemic condition can often result in the production of high reactive/nitrosative oxygen species concentration and possible damage of several cell structures. In the present work attention has been focused on the possible nitrosative effect of hyperglycemia on RT4 Schwannoma cell lines. METHODS Cells were cultured for 72hrs in the presence of 180… CONTINUE READING