Nitrosative modifications of the Ca2+ release complex and actin underlie arthritis-induced muscle weakness

@inproceedings{Yamada2015NitrosativeMO,
  title={Nitrosative modifications of the Ca2+ release complex and actin underlie arthritis-induced muscle weakness},
  author={Takashi Yamada and Olga Fedotovskaya and Arthur J Cheng and Anabelle Silva Cornachione and F{\'a}bio Carderelli Minozzo and Cecilia Aulin and Cecilia Frid{\'e}n and Carl Turesson and Daniel C. Andersson and Birgitta Glenmark and Ingrid E Lundberg and Dilson E Rassier and H{\aa}kan Westerblad and Johanna T Lanner},
  booktitle={Annals of the rheumatic diseases},
  year={2015}
}
OBJECTIVE Skeletal muscle weakness is a prominent clinical feature in patients with rheumatoid arthritis (RA), but the underlying mechanism(s) is unknown. Here we investigate the mechanisms behind arthritis-induced skeletal muscle weakness with special focus on the role of nitrosative stress on intracellular Ca(2+) handling and specific force production. METHODS Nitric oxide synthase (NOS) expression, degree of nitrosative stress and composition of the major intracellular Ca(2+) release… CONTINUE READING

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