Nitrophenylacetonitriles as versatile nucleophiles in enantioselective organocatalytic conjugate additions.


Arylacetonitriles are able to participate in organocatalytic Michael additions to alpha,beta-unsaturated aldehydes by incorporating a nitro group at the phenyl ring, which acts as a temporary activating group in a remote position and allows further transformations. The sequential protocol Michael addition/NaBH(4) reduction/lactonization allows the synthesis… (More)
DOI: 10.1021/ol101178u


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