Nitrones as neuroprotective agents in cerebral ischemia, with particular reference to NXY-059.

@article{Green2003NitronesAN,
  title={Nitrones as neuroprotective agents in cerebral ischemia, with particular reference to NXY-059.},
  author={Alfred Richard Green and Tim J. Ashwood and Tomas Odergren and David Mark Jackson},
  journal={Pharmacology & therapeutics},
  year={2003},
  volume={100 3},
  pages={195-214}
}
Stroke is a major clinical problem, and acute pharmacological intervention with neuroprotective agents has so far been unsuccessful. Recently, there has been considerable interest in the potential therapeutic benefit of nitrone-derived free radical trapping agents as neuroprotective agents. Nitrone compounds have been shown to be beneficial in animal models of various diseases, and the prototypic compound alpha-phenyl-N-tert-butylnitrone (PBN) has been extensively demonstrated to be… CONTINUE READING

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Comparison of neuroprotective data for NXY-059 in animal models with STAIR criteria

  • K. R. Lees, A. R. Green, T. Odergren
  • Cerebrovasc Dis 11(Suppl
  • 2001
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