Nitrolinoleate inhibits platelet activation by attenuating calcium mobilization and inducing phosphorylation of vasodilator-stimulated phosphoprotein through elevation of cAMP.

@article{Coles2002NitrolinoleateIP,
  title={Nitrolinoleate inhibits platelet activation by attenuating calcium mobilization and inducing phosphorylation of vasodilator-stimulated phosphoprotein through elevation of cAMP.},
  author={Barbara C. Coles and Allison Bloodsworth and Jason P. Eiserich and Marcus J. Coffey and Rachel M McLoughlin and John C. Giddings and Malcolm J Lewis and Richard J. Haslam and Bruce A. Freeman and Valerie B O'Donnell},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 8},
  pages={5832-40}
}
Reactive species formed from nitric oxide (NO) nitrate unsaturated fatty acids such as linoleate (LA) to nitrated derivatives including nitrolinoleate (LNO(2)). The effect of LNO(2) on human platelets was examined to define how nitrated lipids might behave in vivo. LNO(2), but not LA or 3-nitrotyrosine, dose dependently (0.5-10 microm) inhibited thrombin-mediated aggregation of washed human platelets, with concomitant attenuation of P-selectin expression and selective phosphorylation of VASP at… CONTINUE READING

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