Nitrolinoleate, a nitric oxide-derived mediator of cell function: synthesis, characterization, and vasomotor activity.

@article{Lim2002NitrolinoleateAN,
  title={Nitrolinoleate, a nitric oxide-derived mediator of cell function: synthesis, characterization, and vasomotor activity.},
  author={Dong Gun Lim and Scott Sweeney and Allison Bloodsworth and Charles R. White and Phillip H Chumley and N. Rama Krishna and Francisco J Schopfer and Valerie B O'Donnell and Jason P. Eiserich and Bruce A. Freeman},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2002},
  volume={99 25},
  pages={15941-6}
}
Nitric oxide (*NO) and *NO-derived reactive species rapidly react with lipids during both autocatalytic and enzymatic oxidation reactions to yield nitrated derivatives that serve as cell signaling molecules. Herein we report the synthesis, purification, characterization, and bioactivity of nitrolinoleate (LNO2). Nitroselenylation of linoleic acid yielded LNO2 that was purified by solvent extraction, silicic acid chromatography, and reverse-phase HPLC. Structural characterization was performed… CONTINUE READING

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