Nitroglycerin upregulates matrix metalloproteinase expression by human macrophages.

  title={Nitroglycerin upregulates matrix metalloproteinase expression by human macrophages.},
  author={Alison K Death and Shirley Nakhla and Kristine C. Y. McGrath and Sally Martell and Dennis Koon-See Yue and Wendy Jessup and David S Celermajer},
  journal={Journal of the American College of Cardiology},
  volume={39 12},
OBJECTIVES This study aimed to determine whether nitroglycerin (NTG) treatment affects matrix metalloproteinase (MMP) gene expression and activities in human macrophages. BACKGROUND Nitroglycerin is one of the most frequently used therapeutic agents for the symptomatic relief of stable or unstable coronary artery disease; however, its effects on vascular biology are poorly characterized. Despite its powerful vasodilator activity, NTG has not been shown to improve outcomes in coronary disease… CONTINUE READING