Nitroglycerin metabolism by Phanerochaete chrysosporium: evidence for nitric oxide and nitrite formation.

@article{Servent1991NitroglycerinMB,
  title={Nitroglycerin metabolism by Phanerochaete chrysosporium: evidence for nitric oxide and nitrite formation.},
  author={Denis Servent and Claire Ducrocq and Yann Henry and Annie Guissani and Maryse Lenfant},
  journal={Biochimica et biophysica acta},
  year={1991},
  volume={1074 2},
  pages={320-5}
}
We have demonstrated that a filamentous fungus Phanerochaete chrysosporium converts glyceryl trinitrate (GTN) into its di- and mononitrate derivatives concurrently with the formation of nitric oxide detected by electron paramagnetic resonance (EPR), and the formation of nitrite. The metabolisms of nitrite and nitrate by the fungus are evaluated and taken into account when considering GTN degradation. Lack of evidence for nitrate formation from GTN suggests that an esterase-type activity is not… CONTINUE READING