Nitroglycerin fails to lower blood pressure in redox-dead Cys42Ser PKG1α knock-in mouse.


BACKGROUND Although nitroglycerin has remained in clinical use since 1879, the mechanism by which it relaxes blood vessels to lower blood pressure remains incompletely understood. Nitroglycerin undergoes metabolism that generates several reaction products, including oxidants, and this bioactivation process is essential for vasodilation. Protein kinase G… (More)
DOI: 10.1161/CIRCULATIONAHA.112.101287


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