Nitrogen sparing induced by leucine compared with that induced by its keto analogue, alpha-ketoisocaproate, in fasting obese man.

@article{Mitch1981NitrogenSI,
  title={Nitrogen sparing induced by leucine compared with that induced by its keto analogue, alpha-ketoisocaproate, in fasting obese man.},
  author={William E. Mitch and Mackenzie Walser and Daniel Sapir},
  journal={The Journal of clinical investigation},
  year={1981},
  volume={67 2},
  pages={553-62}
}
We measured the effects of seven consecutive daily infusions of alpha-ketoisocaproate (the alpha-keto analogue of leucine) or leucine itself on urinary urea and total nitrogen excretion during fasting. Two study protocols were undertaken. In protocol I, subjects underwent three separate 14-d fasts: one during which 34 mmol/d of leucine were infused on days… CONTINUE READING