Nitrogen mustard exposure of murine skin induces DNA damage, oxidative stress and activation of MAPK/Akt-AP1 pathway leading to induction of inflammatory and proteolytic mediators.

Abstract

Our recent studies in SKH-1 hairless mice have demonstrated that topical exposure to nitrogen mustard (NM), an analog of sulfur mustard (SM), triggers the inflammatory response, microvesication and apoptotic cell death. Here, we sought to identify the mechanism/s involved in these NM-induced injury responses. Results obtained show that NM exposure of SKH-1… (More)
DOI: 10.1016/j.toxlet.2015.04.006

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@article{Kumar2015NitrogenME, title={Nitrogen mustard exposure of murine skin induces DNA damage, oxidative stress and activation of MAPK/Akt-AP1 pathway leading to induction of inflammatory and proteolytic mediators.}, author={Dileep Kumar and Neera Tewari-Singh and Chapla Agarwal and Anil K. Jain and Swetha Inturi and Rama Kant and C. Whitney White and Rajesh Agarwal}, journal={Toxicology letters}, year={2015}, volume={235 3}, pages={161-71} }