Nitrogen handling in adult hypothalamic obese rats.

  title={Nitrogen handling in adult hypothalamic obese rats.},
  author={C. Karakash and Françoise Rohner-Jeanrenaud and B. E. Hustvedt and Bernard Jeanrenaud},
  journal={The American journal of physiology},
  volume={238 1},
Several aspects of nitrogen metabolism have been studied in adult nonhyperphagic, hyperinsulinemic, ventromedial hypothalamus (VMH)-lesioned rats. Ten days postoperatively, VMH-lesioned rats had high plasma levels of urea and low plasma tyrosine, while plasma alanine, glutamine, total amino acid, and protein levels were unaltered. Urea production and excretion were increased in VMH-lesioned rats. Increased urea synthesis could not be attributed to enhanced peripheral release of amino acids. In… CONTINUE READING