Nitrogen excretion in developing zebrafish (Danio rerio): a role for Rh proteins and urea transporters.

@article{Braun2009NitrogenEI,
  title={Nitrogen excretion in developing zebrafish (Danio rerio): a role for Rh proteins and urea transporters.},
  author={Marvin H. Braun and Shelby L Steele and M Ekker and Steve F. Perry},
  journal={American journal of physiology. Renal physiology},
  year={2009},
  volume={296 5},
  pages={F994-F1005}
}
Injection of antisense oligonucleotide morpholinos to elicit selective gene knockdown of ammonia (Rhag, Rhbg, and Rhcg1) or urea transporters (UT) was used as a tool to assess the relative importance of each transporter to nitrogen excretion in developing zebrafish (Danio rerio). Knockdown of UT caused urea excretion to decrease by approximately 90%, whereas each of the Rh protein knockdowns resulted in an approximately 50% reduction in ammonia excretion. Contrary to what has been hypothesized… CONTINUE READING
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