Nitrogen dioxide exposure: effects on airway and blood cells.

@article{Frampton2002NitrogenDE,
  title={Nitrogen dioxide exposure: effects on airway and blood cells.},
  author={Mark W Frampton and Joseph A. Boscia and Norbert J. Roberts and Mitra Azadniv and Alfonso Torres and Christopher Cox and Paul E. Morrow and Joan E. Nichols and David C. Chalupa and Lauren M. Frasier and F. Raymond Gibb and Donna M. Speers and Ying Tsai and Mark J. Utell},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={2002},
  volume={282 1},
  pages={
          L155-65
        }
}
  • M. Frampton, J. Boscia, +11 authors M. Utell
  • Published 2002
  • Biology, Medicine
  • American journal of physiology. Lung cellular and molecular physiology
This study examined the effects of nitrogen dioxide (NO(2)) exposure on airway inflammation, blood cells, and antiviral respiratory defense. Twenty-one healthy volunteers were exposed on separate occasions to air and 0.6 and 1.5 ppm NO(2) for 3 h with intermittent moderate exercise. Phlebotomy and bronchoscopy were performed 3.5 h after each exposure, and recovered cells were challenged with respiratory viruses in vitro. Blood studies revealed a 4.1% NO(2) dose-related decrease in hematocrit (P… Expand
Biological effects of inhaled nitrogen dioxide in healthy human subjects
TLDR
The results do not suggest a considerable acute adverse response in human subjects after 3 h of exposure to NO2 in the NO2 concentration range investigated in this study. Expand
Effects of personal nitrogen dioxide exposure on airway inflammation and lung function.
TLDR
Short-term personal exposure to NO2 is associated with NOS2A hypomethylation, ARG2 hypermethylation, respiratory inflammation and lung function impairment, and the use of personal measurements may better predict the respiratory effects of NO2. Expand
Personal exposure to nitrogen dioxide (NO2) and the severity of virus-induced asthma in children
TLDR
High exposure to NO2 in the week before the start of a respiratory viral infection, and at levels within current air quality standards, is associated with an increase in the severity of a resulting asthma exacerbation. Expand
Allergic inflammation in the human lower respiratory tract affected by exposure to diesel exhaust.
TLDR
It is found that cell influx and production of cytokines, chemokines, immunoglobulin E, and other mediators occur in people with asthma after realistic controlled exposures to diesel exhaust (DE), but not in patterns consistent with the primary hypothesis. Expand
Effects of Nitrogen Dioxide on the Expression of Intercellular Adhesion Molecule-1, Neutrophil Adhesion, and Cytotoxicity: Studies in Human Bronchial Epithelial Cells
TLDR
It is demonstrated that the NHBE cells undergo apoptotic cell death during the early post-NO2 period, but this is independent of any significant increase in caspase-3 activity, and Therapeutic strategies aimed at controlling excess generation of NO and/or inflammatory cytokines may be useful in alleviating NO2-mediated adverse effects on the bronchial epithelium. Expand
Particulate matter and oxidative stress: dangerous partners in inflammation, vascular dysfunction and innate immunity
TLDR
Current knowledge is reviewed and a model in which PM-induced oxidative stress initiates innate immune and inflammatory responses that result in pulmonary and systemic vascular dysfunction is proposed that may lead to acute exacerbation of disease following acute exposures, and initiate disease with long-term exposure. Expand
In vivo screening to determine neurological hazards of nitrogen dioxide (NO2) using Wistar rats.
TLDR
The present report provided essential information for the characterization of the neurotoxic hazard of NO(2) and related mechanisms, which is required in response to the general concern about the vulnerability of the neurological system to it. Expand
Effect of Nitrogen Dioxide Inhalation on Blood Glucose Level in Albino Rat
The fate of inhaled nitrogen dioxide was studied with blood of albino rat. Nitrogen Dioxide is an oxidant air pollutant which induced pulmonary injury in albino rats. We evaluated the effects of 35Expand
Exposure to air pollution and pulmonary function in university students
TLDR
It is indicated that concentrations of personal exposure to NO2 are significantly influenced by traffic-related air pollution and are associated with decreased pulmonary function. Expand
Effects of air pollution on red blood cells in children
TLDR
Air pollution could have negative effects on red blood cells in children, and the red blood cell count and average of hemoglobin blood levels of exposed children differ significantly from those of the non-exposed (P<0.001). Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 60 REFERENCES
Effect of serial-day exposure to nitrogen dioxide on airway and blood leukocytes and lymphocyte subsets.
TLDR
Exposure to nitrogen dioxide results in bronchial inflammation and a minimal change in bronchoalveolar lavage T-helper cells, and no changes in peripheral blood cells. Expand
The inflammatory effects of 2 ppm NO2 on the airways of healthy subjects.
TLDR
NO2 induced a neutrophilic inflammation in the airways that was detectable in BW at 6 h after NO2 exposure, and the absence of adhesion-molecule upregulation or cellular inflammation in mucosal biopsy specimens indicates that the major site of inflammation following exposure to NO2 may be in the smaller airways and not in the alveoli. Expand
Effects of repeated exposure to 4 ppm nitrogen dioxide on bronchoalveolar lymphocyte subsets and macrophages in healthy men.
TLDR
Analysis of the recovered BAL fluid demonstrated that repeated exposures to NO2 caused a lung cell response different from that reported after a single exposure, suggesting that repeated exposure with NO2 adversely affects the immune defence. Expand
Effects of 0.60 PPM nitrogen dioxide on circulating and bronchoalveolar lavage lymphocyte phenotypes in healthy subjects.
TLDR
It is suggested that brief, daily exposures to NO2 at levels higher than those achieved in urban atmosphere are unlikely to provoke acute respiratory impairment in healthy, nonsmoking adults. Expand
Persistent airway inflammation but accommodated antioxidant and lung function responses after repeated daily exposure to nitrogen dioxide.
TLDR
The data indicate that four sequential exposures to NO2 result in a persistent neutrophilic inflammation in the airways, whereas changes in pulmonary function and airway antioxidants are resolved. Expand
Effects of nitrogen dioxide exposure on pulmonary function and airway reactivity in normal humans.
TLDR
Assessment of effects of various levels and patterns of NO2 exposure on pulmonary function and airway reactivity in normal humans concludes that for subjects without airway hyperreactivity, exposure to 1.5 ppm NO2 for 3 h increases airways reactivity, whereas repeated 15-min exposures to 2.0 ppm No2 do not alter airway reactsivity. Expand
Nitrogen dioxide inhalation and human blood biochemistry.
TLDR
It was concluded that significant blood biochemical changes resulted from NO2 inhalation, although the three-day experimental regimen independently produced changes that account for some of the apparent response. Expand
Nitrogen dioxide exposure in vivo and human alveolar macrophage inactivation of influenza virus in vitro.
TLDR
Normal volunteers were exposed sequentially to air or NO2, by double-blind randomization, in an environmental chamber to examine the effect of NO2 inhalation on human alveolar macrophages, which has the potential to identify pollutant effects on mechanisms of respiratory defense in humans. Expand
Modulation of pulmonary defense mechanisms by acute exposures to nitrogen dioxide.
  • G. J. Jakab
  • Biology, Medicine
  • Experientia. Supplementum
  • 1987
The effect of acute exposures to NO/sub 2/ on the antibacterial defenses of the murine lung was assessed following inhalation challenges with Staphylococcus aureus, Proteus mirabilis, and PasteurellaExpand
Reductions in lymphocyte subpopulations after repeated exposure to 1.5 ppm nitrogen dioxide.
TLDR
It is concluded that repeated short term exposures to 1.5 ppm NO2, a moderate occupational concentration, induces significant effects on immune competent bronchoalveolar lymphocytes, indicating that previous findings of changes in the lymphoid immune system induced by NO2 in animals may well be applicable to humans. Expand
...
1
2
3
4
5
...