Nitrogen assimilation in Escherichia coli: putting molecular data into a systems perspective.

@article{Heeswijk2013NitrogenAI,
  title={Nitrogen assimilation in Escherichia coli: putting molecular data into a systems perspective.},
  author={Wally C van Heeswijk and Hans V. Westerhoff and Fred C. Boogerd},
  journal={Microbiology and molecular biology reviews : MMBR},
  year={2013},
  volume={77 4},
  pages={
          628-95
        }
}
We present a comprehensive overview of the hierarchical network of intracellular processes revolving around central nitrogen metabolism in Escherichia coli. The hierarchy intertwines transport, metabolism, signaling leading to posttranslational modification, and transcription. The protein components of the network include an ammonium transporter (AmtB), a glutamine transporter (GlnHPQ), two ammonium assimilation pathways (glutamine synthetase [GS]-glutamate synthase [glutamine 2-oxoglutarate… CONTINUE READING
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