Nitrogen Metabolite Repression of Metabolism and Virulence in the Human Fungal Pathogen Cryptococcus neoformans

@article{Lee2011NitrogenMR,
  title={Nitrogen Metabolite Repression of Metabolism and Virulence in the Human Fungal Pathogen Cryptococcus neoformans},
  author={I. Russel Lee and Eve W L Chow and Carl A. Morrow and Julianne Teresa Djordjevic and James Angus Fraser},
  journal={Genetics},
  year={2011},
  volume={188},
  pages={309 - 323}
}
Proper regulation of metabolism is essential to maximizing fitness of organisms in their chosen environmental niche. Nitrogen metabolite repression is an example of a regulatory mechanism in fungi that enables preferential utilization of easily assimilated nitrogen sources, such as ammonium, to conserve resources. Here we provide genetic, transcriptional, and phenotypic evidence of nitrogen metabolite repression in the human pathogen Cryptococcus neoformans. In addition to loss of… 

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