Nitrofurantoin safety and effectiveness in treating acute uncomplicated cystitis (AUC) in hospitalized adults with renal insufficiency: antibiotic stewardship implications

@article{Cunha2017NitrofurantoinSA,
  title={Nitrofurantoin safety and effectiveness in treating acute uncomplicated cystitis (AUC) in hospitalized adults with renal insufficiency: antibiotic stewardship implications},
  author={Burke A. Cunha and Cheston B. Cunha and Brian Kin Hang Lam and J. Giuga and James Chin and Veronica Zafonte and Steve Gerson},
  journal={European Journal of Clinical Microbiology \& Infectious Diseases},
  year={2017},
  volume={36},
  pages={1213-1216}
}
  • B. Cunha, C. Cunha, +4 authors S. Gerson
  • Published 2017
  • Medicine
  • European Journal of Clinical Microbiology & Infectious Diseases
Nitrofurantoin remains a key oral antibiotic stewardship program (ASP) option in the treatment of acute uncomplicated cystitis (AUC) due to multi-drug resistant (MDR) Gram negative bacilli (GNB). However, there have been concerns regarding decreased nitrofurantoin efficacy with renal insufficiency. In our experience over the past three decades, nitrofurantoin has been safe and effective in treating AUC in hospitalized adults with renal insufficiency. Accordingly, we retrospectively reviewed our… Expand
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Colistin and fosfomycin remains the most sensitive antibiotic while nitrofurantoin still preserves the good sensitivity against ESBL and found to be an only oral sensitive antibiotic. Expand
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