Nitrofurantoin Contraindication in Patients with a Creatinine Clearance Below 60 mL/min: Looking for the Evidence

  title={Nitrofurantoin Contraindication in Patients with a Creatinine Clearance Below 60 mL/min: Looking for the Evidence},
  author={Mandy Oplinger and Carlota O Andrews},
  journal={Annals of Pharmacotherapy},
  pages={106 - 111}
  • Mandy Oplinger, Carlota O Andrews
  • Published 2013
  • Medicine
  • Annals of Pharmacotherapy
  • OBJECTIVE To investigate the evidence leading to nitrofurantoin contraindication in patients with a creatinine clearance (CrCl) below 60 mL/min. DATA SOURCES Literature was searched in PubMed (1965-June 2012) by using the key words and MeSH terms urinary tract infections-drug therapy, chronic kidney insufficiency, kidney diseases, pharmacokinetics, safety, and efficacy, combined with nitrofurantoin. Articles were limited to the English language. References from the identified studies, Food and… CONTINUE READING
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