Nitrobenzyl radical metabolites from microsomal reduction of nitrobenzyl chlorides.

@article{Moreno1986NitrobenzylRM,
  title={Nitrobenzyl radical metabolites from microsomal reduction of nitrobenzyl chlorides.},
  author={Silvia N. J. Moreno and J{\"o}rg Schreiber and Ronald Paul Mason},
  journal={The Journal of biological chemistry},
  year={1986},
  volume={261 17},
  pages={7811-5}
}
The o-, m-, and p-nitrobenzyl chlorides are reduced aerobically and anaerobically by NADPH and rat hepatic microsomes. Under aerobic conditions, these nitro anion radicals reduce oxygen to superoxide as demonstrated by oxygen consumption and spin trapping of superoxide with 5,5-dimethyl-1-pyrroline N-oxide. At low oxygen concentration, the p- and o-nitro anion radicals undergo intramolecular electron transfer and decompose to carbon-centered nitrobenzyl radicals, which can be spin-trapped with… CONTINUE READING