Nitroarginine inhibits endothelium-derived relaxation.

  title={Nitroarginine inhibits endothelium-derived relaxation.},
  author={Yuta Kobayashi and Kaoru Hattori},
  journal={Japanese journal of pharmacology},
  volume={52 1},
Effects of NG-nitro-L-arginine (NO2Arg), a guanidinonitro arginine derivative, on acetylcholine-induced relaxation of rabbit thoracic aorta ring preparation were studied. Relaxation by acetylcholine was inhibited by NO2Arg dose-dependently and the maximum relaxation with 10(2) microM NO2Arg was reduced to 10.1 +/- 4.3% (n = 5). L-arginine (10(2) microM) did… CONTINUE READING